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The Human Papillomavirus E7 oncoprotein plays an essential role in the development and maintenance of malignancy, which it achieves through targeting a number of critical cell con- trol pathways. An important element in the ability of E7 to contribute towards cell transforma- tion is the presence of a Casein Kinase...

Anti-tuberculosis (TB) drugs, while being highly potent in vitro, require prolonged treatment to control Mycobacterium tuberculosis (Mtb) infections in vivo. This research article reports here that mesenchymal stem cells (MSCs) shelter Mtb to help tolerate anti-TB drugs. MSCs readily take up Mtb and allow unabated mycobacterial growth despite having a...

The innate response to a pathogen is critical in determining the outcome of the infection. However, the interplay of different cellular responses that are activated following viral infection and their contribution to innate antiviral signalling has not been clearly established. This work shows that flaviviruses, including Dengue, Zika, West Nile...

In 2019, over 600 scientists representing more than 47 nationalities were on board in the ICGEB laboratories, undertaking research across five macro-areas (Infectious Diseases, Non- Communicable Diseases, Medical Biotechnology, Industrial Biotechnology, and Plant Biology and Biotechnology). In Trieste, 18 Research Groups, comprising over 170 researchers have been active in various...

Acknowledging the challenges posed by the foreign fighter phenomenon and the urgent need to address the needs and protect the rights of children affected by it, some Member States have requested practical guidance on how to take appropriate measures towards such children while also fulfilling their obligations under international human...

The present handbook is an initiative of Counter-Terrorism Implementation Task Force (CTITF) Working Group on Protecting Human Rights while Countering Terrorism. The handbook, and a sister pocketbook, aim to assist the Member States in strengthening the protection of human rights in border security and management in the context of counter-terrorism,...